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June 16, 2019  
UTERINE NEWS: Feature Story

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  • postpartum

    Postpartum Depression Seen in the Brain


    September 18, 2010

    Source: American Psychiatric Association

    Women with postpartum depression who viewed pictures of scared or angry faces had less activity as shown by functional magnetic resonance brain imaging than did healthy mothers in the dorsomedial prefrontal cortex, a part of the brain that controls emotional responses and recognizes emotional cues in others. The mothers with postpartum depression also had less communication between this area and the amygdala, the hub of emotional conditioning.


    Take Action
    How to Treat Symptoms
    of Postpartum Depression  


  • Join a support group for
    new mothers.

  • Don't neglect yourself.
    Take some me time while
    the baby is sleeping.
    Relax, read a book, take
    a bath, or catch some
    quick z's.

  • Schedule alone time
    with your husband. Try to
    go out on a date at least
    once every week or two.

  • Eat three balanced
    meals a day. A healthy
    diet increases your
    energy and elevates
    your mood.

  • Talk to a professional
    about any symptoms that
    last more than two weeks.



  • Previous research on postpartum depression has primarily focused on hormonal factors. These new functional MRI findings by Eydie Moses-Kolko, M.D., and colleagues at the University of Pittsburgh indicate that it is the brain biology of peripartum depression that seems to interfere with responding to emotional cues. This deficit may underlie decreased bonding to the infant, the biggest problem with the disorder. 

    The depressed mothers' clinical state correlated with amygdala responses to the scared or angry faces. Within this group, lower activity in the left amygdala was associated with greater depression severity, and lower activity in the right amygdala was correlated with greater hostility toward the infant. 

    Dr. Moses-Kolko stated, "Finding abnormalities in these two brain regions, and in the connection between them, suggests that mothers with postpartum depression have problems in the neural circuitry underlying not only their own emotions but their attunement to the emotions of others. This could interfere with the bonding between the mothers and their infants and have important repercussions for the offspring later in life. Ultimately, clarifying brain mechanisms of mother-infant attachment has the potential to guide the development of more effective treatments for postpartum depression." 

    The study of 14 depressed mothers and 16 healthy mothers will appear on September 15 at AJP in Advance, the online advance edition of The American Journal of Psychiatry (AJP), the official journal of the American Psychiatric Association. This study was funded by the National Institute of Mental Health, NARSAD, and the University of Pittsburgh.

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    Photo: Cia de Foto 

     

    Last updated: 18-Sep-10

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